গ্রন্থ-পঞ্জীর বিবরন
| আখ্যা: |
Potential for Antigen-Specific Tolerizing Immunotherapy in Systematic Lupus Erythematosus |
| লেখক: |
Sean Robinson, Ranjeny Thomas |
| সম্পদ: |
Frontiers in Immunology, Vol 12 (2021) |
| প্রকাশকের তথ্য: |
Frontiers Media S.A., 2021. |
| প্রকাশনার সাল: |
2021 |
| সংগ্রহ: |
LCC:Immunologic diseases. Allergy |
| বিষয়ের শর্তাবলী: |
systemic lupus erythematosis, tolerance, dendritic cells, antigen (Ag), immunotherapies and vaccines, Immunologic diseases. Allergy, RC581-607 |
| বিবরন: |
Systemic lupus erythematosus (SLE) is a chronic complex systemic autoimmune disease characterized by multiple autoantibodies and clinical manifestations, with the potential to affect nearly every organ. SLE treatments, including corticosteroids and immunosuppressive drugs, have greatly increased survival rates, but there is no curative therapy and SLE management is limited by drug complications and toxicities. There is an obvious clinical need for safe, effective SLE treatments. A promising treatment avenue is to restore immunological tolerance to reduce inflammatory clinical manifestations of SLE. Indeed, recent clinical trials of low-dose IL-2 supplementation in SLE patients showed that in vivo expansion of regulatory T cells (Treg cells) is associated with dramatic but transient improvement in SLE disease markers and clinical manifestations. However, the Treg cells that expanded were short-lived and unstable. Alternatively, antigen-specific tolerance (ASIT) approaches that establish long-lived immunological tolerance could be deployed in the context of SLE. In this review, we discuss the potential benefits and challenges of nanoparticle ASIT approaches to induce prolonged immunological tolerance in SLE. |
| প্রলেখের ধরণ: |
article |
| ফাইলের বিবরণ: |
electronic resource |
| ভাষা: |
English |
| আইএসএসএন: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.654701/full; https://doaj.org/toc/1664-3224 |
| ডিওআই: |
10.3389/fimmu.2021.654701 |
| URL ব্যবহার করুন: |
https://doaj.org/article/f74f270687bd4847a5553cfbaa71279a |
| পরিগ্রহন সংখ্যা: |
edsdoj.f74f270687bd4847a5553cfbaa71279a |
| উপাত্তকোষ: |
Directory of Open Access Journals |