Библиографические подробности
| Заглавие: |
Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022 |
| Авторы: |
Catherine Hyams, Robert Challen, David Hettle, Zahin Amin-Chowdhury, Charli Grimes, Gabriella Ruffino, Rauri Conway, Robyn Heath, Paul North, Adam Malin, Nick A. Maskell, Philip Williams, O. Martin Williams, Shamez N. Ladhani, Leon Danon, Adam Finn |
| Источник: |
Emerging Infectious Diseases, Vol 29, Iss 10, Pp 1953-1964 (2023) |
| Издатель: |
Centers for Disease Control and Prevention, 2023. |
| Год публикации: |
2023 |
| Коллекция: |
LCC:Medicine
LCC:Infectious and parasitic diseases |
| Термины предметов: |
pneumonia, Streptococcus pneumoniae, bacteria, pneumococcus, serotypes, serotype distribution, Medicine, Infectious and parasitic diseases, RC109-216 |
| Описание: |
Ongoing surveillance after pneumococcal conjugate vaccination (PCV) deployment is essential to inform policy decisions and monitor serotype replacement. We report serotype and disease severity trends in 3,719 adults hospitalized for pneumococcal disease in Bristol and Bath, United Kingdom, during 2006–2022. Of those cases, 1,686 were invasive pneumococcal disease (IPD); 1,501 (89.0%) had a known serotype. IPD decreased during the early COVID-19 pandemic but during 2022 gradually returned to prepandemic levels. Disease severity changed throughout this period: CURB65 severity scores and inpatient deaths decreased and ICU admissions increased. PCV7 and PCV13 serotype IPD decreased from 2006–2009 to 2021–2022. However, residual PCV13 serotype IPD remained, representing 21.7% of 2021–2022 cases, indicating that major adult PCV serotype disease still occurs despite 17 years of pediatric PCV use. Percentages of serotype 3 and 8 IPD increased, and 19F and 19A reemerged. In 2020–2022, a total of 68.2% IPD cases were potentially covered by PCV20. |
| Тип документа: |
article |
| Описание файла: |
electronic resource |
| Язык: |
English |
| ISSN: |
1080-6040
1080-6059 |
| Relation: |
https://wwwnc.cdc.gov/eid/article/29/10/23-0519_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: |
10.3201/eid2910.230519 |
| Доступ через URL: |
https://doaj.org/article/3e8fda4e704548b4908fbd8835008fa9 |
| Номер доступа: |
edsdoj.3e8fda4e704548b4908fbd8835008fa9 |
| База данных: |
Directory of Open Access Journals |