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Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022

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Title: Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022
Authors: Catherine Hyams, Robert Challen, David Hettle, Zahin Amin-Chowdhury, Charli Grimes, Gabriella Ruffino, Rauri Conway, Robyn Heath, Paul North, Adam Malin, Nick A. Maskell, Philip Williams, O. Martin Williams, Shamez N. Ladhani, Leon Danon, Adam Finn
Source: Emerging Infectious Diseases, Vol 29, Iss 10, Pp 1953-1964 (2023)
Publisher Information: Centers for Disease Control and Prevention, 2023.
Publication Year: 2023
Collection: LCC:Medicine
LCC:Infectious and parasitic diseases
Subject Terms: pneumonia, Streptococcus pneumoniae, bacteria, pneumococcus, serotypes, serotype distribution, Medicine, Infectious and parasitic diseases, RC109-216
Description: Ongoing surveillance after pneumococcal conjugate vaccination (PCV) deployment is essential to inform policy decisions and monitor serotype replacement. We report serotype and disease severity trends in 3,719 adults hospitalized for pneumococcal disease in Bristol and Bath, United Kingdom, during 2006–2022. Of those cases, 1,686 were invasive pneumococcal disease (IPD); 1,501 (89.0%) had a known serotype. IPD decreased during the early COVID-19 pandemic but during 2022 gradually returned to prepandemic levels. Disease severity changed throughout this period: CURB65 severity scores and inpatient deaths decreased and ICU admissions increased. PCV7 and PCV13 serotype IPD decreased from 2006–2009 to 2021–2022. However, residual PCV13 serotype IPD remained, representing 21.7% of 2021–2022 cases, indicating that major adult PCV serotype disease still occurs despite 17 years of pediatric PCV use. Percentages of serotype 3 and 8 IPD increased, and 19F and 19A reemerged. In 2020–2022, a total of 68.2% IPD cases were potentially covered by PCV20.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1080-6040
1080-6059
Relation: https://wwwnc.cdc.gov/eid/article/29/10/23-0519_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059
DOI: 10.3201/eid2910.230519
Access URL: https://doaj.org/article/3e8fda4e704548b4908fbd8835008fa9
Accession Number: edsdoj.3e8fda4e704548b4908fbd8835008fa9
Database: Directory of Open Access Journals
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  Data: Serotype Distribution and Disease Severity in Adults Hospitalized with Streptococcus pneumoniae Infection, Bristol and Bath, UK, 2006‒2022
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  Data: <searchLink fieldCode="AR" term="%22Catherine+Hyams%22">Catherine Hyams</searchLink><br /><searchLink fieldCode="AR" term="%22Robert+Challen%22">Robert Challen</searchLink><br /><searchLink fieldCode="AR" term="%22David+Hettle%22">David Hettle</searchLink><br /><searchLink fieldCode="AR" term="%22Zahin+Amin-Chowdhury%22">Zahin Amin-Chowdhury</searchLink><br /><searchLink fieldCode="AR" term="%22Charli+Grimes%22">Charli Grimes</searchLink><br /><searchLink fieldCode="AR" term="%22Gabriella+Ruffino%22">Gabriella Ruffino</searchLink><br /><searchLink fieldCode="AR" term="%22Rauri+Conway%22">Rauri Conway</searchLink><br /><searchLink fieldCode="AR" term="%22Robyn+Heath%22">Robyn Heath</searchLink><br /><searchLink fieldCode="AR" term="%22Paul+North%22">Paul North</searchLink><br /><searchLink fieldCode="AR" term="%22Adam+Malin%22">Adam Malin</searchLink><br /><searchLink fieldCode="AR" term="%22Nick+A%2E+Maskell%22">Nick A. Maskell</searchLink><br /><searchLink fieldCode="AR" term="%22Philip+Williams%22">Philip Williams</searchLink><br /><searchLink fieldCode="AR" term="%22O%2E+Martin+Williams%22">O. Martin Williams</searchLink><br /><searchLink fieldCode="AR" term="%22Shamez+N%2E+Ladhani%22">Shamez N. Ladhani</searchLink><br /><searchLink fieldCode="AR" term="%22Leon+Danon%22">Leon Danon</searchLink><br /><searchLink fieldCode="AR" term="%22Adam+Finn%22">Adam Finn</searchLink>
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  Data: Emerging Infectious Diseases, Vol 29, Iss 10, Pp 1953-1964 (2023)
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  Data: <searchLink fieldCode="DE" term="%22pneumonia%22">pneumonia</searchLink><br /><searchLink fieldCode="DE" term="%22Streptococcus+pneumoniae%22">Streptococcus pneumoniae</searchLink><br /><searchLink fieldCode="DE" term="%22bacteria%22">bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22pneumococcus%22">pneumococcus</searchLink><br /><searchLink fieldCode="DE" term="%22serotypes%22">serotypes</searchLink><br /><searchLink fieldCode="DE" term="%22serotype+distribution%22">serotype distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Infectious+and+parasitic+diseases%22">Infectious and parasitic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22RC109-216%22">RC109-216</searchLink>
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  Data: Ongoing surveillance after pneumococcal conjugate vaccination (PCV) deployment is essential to inform policy decisions and monitor serotype replacement. We report serotype and disease severity trends in 3,719 adults hospitalized for pneumococcal disease in Bristol and Bath, United Kingdom, during 2006–2022. Of those cases, 1,686 were invasive pneumococcal disease (IPD); 1,501 (89.0%) had a known serotype. IPD decreased during the early COVID-19 pandemic but during 2022 gradually returned to prepandemic levels. Disease severity changed throughout this period: CURB65 severity scores and inpatient deaths decreased and ICU admissions increased. PCV7 and PCV13 serotype IPD decreased from 2006–2009 to 2021–2022. However, residual PCV13 serotype IPD remained, representing 21.7% of 2021–2022 cases, indicating that major adult PCV serotype disease still occurs despite 17 years of pediatric PCV use. Percentages of serotype 3 and 8 IPD increased, and 19F and 19A reemerged. In 2020–2022, a total of 68.2% IPD cases were potentially covered by PCV20.
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  Data: https://wwwnc.cdc.gov/eid/article/29/10/23-0519_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059
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        PageCount: 12
        StartPage: 1953
    Subjects:
      – SubjectFull: pneumonia
        Type: general
      – SubjectFull: Streptococcus pneumoniae
        Type: general
      – SubjectFull: bacteria
        Type: general
      – SubjectFull: pneumococcus
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      – SubjectFull: serotypes
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