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Simvastatin activates the PPARγ-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.

著者: Zou C; Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou 215006, People's Republic of China. nkzc75@163.com, Qi H, Liu ZH, Han L, Zhao C, Yang X

ソース: Texas Heart Institute journal [Tex Heart Inst J] 2013; Vol. 40 (2), pp. 140-7.

出版種別: Journal Article

雑誌情報: Publisher: published in the Cardiovascular Surgical Research Laboratories, Texas Heart Institute Country of Publication: United States NLM ID: 8214622 Publication Model: Print Cited Medium: Internet ISSN: 1526-6702 (Electronic) Linking ISSN: 07302347 NLM ISO Abbreviation: Tex Heart Inst J Subsets: MEDLINE

MeSH用語: Heart Failure/*drug therapy , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology , Hypertrophy, Left Ventricular/*prevention & control , Myocardium/*enzymology , PPAR gamma/*drug effects , Signal Transduction/*drug effects , Simvastatin/*pharmacology , rhoA GTP-Binding Protein/*metabolism, Animals ; Disease Models, Animal ; Fibrosis ; Heart Failure/diagnostic imaging ; Heart Failure/enzymology ; Heart Failure/physiopathology ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/enzymology ; Hypertrophy, Left Ventricular/physiopathology ; Myocardium/pathology ; PPAR gamma/genetics ; PPAR gamma/metabolism ; RNA, Messenger/metabolism ; Rabbits ; Transcription Factor RelA/metabolism ; Ultrasonography

Doxorubicin-induced cardiomyopathy 17 years after chemotherapy.

著者: Kumar S; Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA., Marfatia R, Tannenbaum S, Yang C, Avelar E

ソース: Texas Heart Institute journal [Tex Heart Inst J] 2012; Vol. 39 (3), pp. 424-7.

出版種別: Case Reports; Journal Article

雑誌情報: Publisher: published in the Cardiovascular Surgical Research Laboratories, Texas Heart Institute Country of Publication: United States NLM ID: 8214622 Publication Model: Print Cited Medium: Internet ISSN: 1526-6702 (Electronic) Linking ISSN: 07302347 NLM ISO Abbreviation: Tex Heart Inst J Subsets: MEDLINE

MeSH用語: Antibiotics, Antineoplastic/*adverse effects , Breast Neoplasms/*drug therapy , Cardiomyopathies/*chemically induced , Doxorubicin/*adverse effects, Breast Neoplasms/surgery ; Cardiomyopathies/diagnosis ; Cardiomyopathies/drug therapy ; Cardiomyopathies/physiopathology ; Cardiovascular Agents/therapeutic use ; Chemotherapy, Adjuvant ; Electrocardiography ; Female ; Heart Failure/chemically induced ; Heart Failure/physiopathology ; Humans ; Magnetic Resonance Imaging ; Mastectomy, Segmental ; Middle Aged ; Recovery of Function ; Stroke Volume ; Time Factors ; Treatment Outcome ; Ventricular Dysfunction, Left/chemically induced ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Function, Left