The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

Authors: vom Saal, Frederick S.¹ vomsaalf@missouri.edu, Antoniou, Michael², Belcher, Scott M.³, Bergman, Ake⁴, Bhandari, Ramji K.¹, Birnbaum, Linda S.^5,6, Cohen, Aly⁷, Collins, Terrence J.⁸, Demeneix, Barbara⁹, Fine, Anne Marie¹⁰, Flaws, Jodi A.¹¹, Gayrard, Veronique¹², Goodson III, William H.¹³, Gore, Andrea C.¹⁴, Heindel, Jerrold J.¹⁵, Hunt, Patricia A.¹⁶, Taisen Iguchi¹⁷, Kassotis, Christopher D.^18,19, Kortenkamp, Andreas²⁰, Mesnage, Robin²

Source: Environmental Health Perspectives. Apr2024, Vol. 132 Issue 4, p045001-1-045001-16. 16p.

Subject Terms: *Environmental health, *Food consumption, *Hazardous substance release, *Food safety, *Phenols, *Environmental exposure, *Endocrine disruptors, Food contamination prevention, Risk assessment, Government agencies, Body weight, Dose-effect relationship in pharmacology, Government regulation

Geographic Terms: Germany

Company/Entity: United States. Food & Drug Administration

Empirical Comparison of Five Parametric Curves in Fifty Dose-Response Studies.

Authors: Hopkins, Grant T.^1,2 (AUTHOR), Liu, Charles C.² (AUTHOR) cliu17@gilead.com, Wang, Ya² (AUTHOR), Yu, Ron Xiaolong² (AUTHOR)

Source: Statistics in Biopharmaceutical Research. May2025, p1-10. 10p. 13 Illustrations.

Subject Terms: *DOSE-effect relationship in pharmacology, *STATISTICAL models, *STATISTICS, *GOODNESS-of-fit tests, *COMPARATIVE studies, *CLUSTER analysis (Statistics), *PARAMETRIC equations

How much furosemide should be administered to prevent transfusion‐associated circulatory overload? Results of a dose‐finding study.

Authors: Rotin, Lianne¹ (AUTHOR), Zhang, Liying² (AUTHOR), Armali, Chantal² (AUTHOR), Malkin, Amie² (AUTHOR), Massin, Sophia² (AUTHOR), Meirovich, Harley² (AUTHOR), Roque, Daniel² (AUTHOR), Saeed, Samia² (AUTHOR), Vijenthira, Shangari² (AUTHOR), Lin, Yulia^1,2,3 (AUTHOR), Pendergrast, Jacob^1,2,4 (AUTHOR) jacob.pendergrast@uhn.ca

Source: Vox Sanguinis. Apr2025, p1. 11p. 3 Illustrations.

Subject Terms: *FUROSEMIDE, *DOSE-effect relationship in pharmacology, *CLINICAL trials, *DIURETICS, *HYPERVOLEMIA, *URINE

A novel approach for first‐in‐human dose selection using population dose–response modelling to find a minimum anticipated biological effect level.

Authors: Yuan, Lin¹ (AUTHOR), Kulkarni, Meghana² (AUTHOR), Chiswick, Evan² (AUTHOR), Koh, Cheryl² (AUTHOR), Sandy, Peter² (AUTHOR), Nabhan, Salah² (AUTHOR), Sherman, Woody² (AUTHOR), Johnson, Melissa³ (AUTHOR), Wang, Judy⁴ (AUTHOR), Falchook, Gerald⁵ (AUTHOR), Johnson, Jennifer⁶ (AUTHOR), Winter, Christopher² (AUTHOR), Gardner, Humphrey² (AUTHOR), Chakravarty, Arijit¹ (AUTHOR), Stoddard, Madison¹ (AUTHOR) madison.stoddard@fractaltx.com

Source: British Journal of Clinical Pharmacology. Apr2025, p1. 12p. 6 Illustrations.

Subject Terms: *SAFETY, *DOSE-effect relationship in pharmacology, *CYTOKINES, *POPULATION dynamics, *TRANSLATIONAL research, *DIAGNOSIS

HTSplotter: An end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening.

Authors: Nunes, Carolina^1,2,3,4 (AUTHOR), Anckaert, Jasper^3,5 (AUTHOR), De Vloed, Fanny^2,3 (AUTHOR), De Wyn, Jolien^2,3 (AUTHOR), Durinck, Kaat^2,3 (AUTHOR), Vandesompele, Jo^3,5 (AUTHOR), Speleman, Frank^2,3 (AUTHOR), Vermeirssen, Vanessa^1,2,3,4 (AUTHOR) vanessa.vermeirssen@ugent.be

Source: PLoS ONE. 1/5/2024, Vol. 19 Issue 1, p1-19. 19p.

Subject Terms: *DOSE-effect relationship in pharmacology, *ELECTRONIC data processing, *DRUG synergism, *PYTHON programming language, *HIGH throughput screening (Drug development), *PDF (Computer file format), *TEXT files

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models.

Authors: Yumin Zhu¹, Xiaoyu Pan², Yibo Jia¹, Xin Yang¹, Xiaohua Song¹, Jiaqi Ding¹, Wenjue Zhong¹, Jianfeng Feng¹, Lingyan Zhu¹ zhuly@nankai.edu.cn

Source: Environmental Health Perspectives. Dec2023, Vol. 131 Issue 12, p127012-1-127012-13. 13p.

Subject Terms: *Bioavailability, *Animal experimentation, *Fluorocarbons, *Toxicity testing, *Environmental exposure, Biological models, In vivo studies, Oral drug administration, Calibration, Regression analysis, Dose-effect relationship in pharmacology, Descriptive statistics, Research funding, Inhalation administration, Cutaneous therapeutics, Data analysis software, Mice

Quantitative Integration of Mode of Action Information in Dose-Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD.

Authors: Qiran Chen¹, Yun Zhou², Chao Ji², Klaunig, James E.², Kan Shao² kshao@indiana.edu

Source: Environmental Health Perspectives. Dec2023, Vol. 131 Issue 12, p127022-1-127022-11. 11p.

Subject Terms: *Carcinogens, *Animal experimentation, *Dioxins, Liver tumors, In vivo studies, Antineoplastic agents, Risk assessment, Conceptual structures, Rats, Dose-effect relationship in pharmacology, Tumors, Data analysis software

Targeted randomization dose optimization trials enable fractional dosing of scarce drugs.

Authors: Boonstra, Philip S.^1,2 (AUTHOR), Tabarrok, Alex³ (AUTHOR), Strohbehn, Garth W.^2,4,5,6,7 (AUTHOR) gstrohbe@umich.edu

Source: PLoS ONE. 10/30/2023, Vol. 18 Issue 10, p1-16. 16p.

Subject Terms: *DOSE-effect relationship in pharmacology, *DRUG efficacy, *DRUG development

Dose-effect relationship of copolymer on enhancing aqueous lubrication of a hybrid osteoarthritis drug delivery nanocarrier.

Authors: Tian, Lejie¹ (AUTHOR), Han, Sirui¹ (AUTHOR), Wu, Wei¹ (AUTHOR), Li, Zhihuan¹ (AUTHOR), He, Zhengze¹ (AUTHOR), Liu, Chen¹ (AUTHOR), Xue, Huidan² (AUTHOR), Zhou, Feng³ (AUTHOR), Liu, Weimin^1,3 (AUTHOR), Liu, Jianxi¹ (AUTHOR) jianxiliu@nwpu.edu.cn

Source: Journal of Colloid & Interface Science. Feb2025:Part B, Vol. 679, p788-797. 10p.

Subject Terms: *DOSE-effect relationship in pharmacology, *ETHYLENE glycol, *TRANSITION temperature, *METAL-organic frameworks, *ANTI-inflammatory agents, *THERMORESPONSIVE polymers

Prolonged use of chlormadinone acetate and risk of intracranial meningioma: A population‐based cohort study.

Authors: Roland, Noémie¹ (AUTHOR) noemie.roland@assurance‐maladie.fr, Nguyen, Pierre¹ (AUTHOR), Neumann, Anke¹ (AUTHOR), Hoisnard, Léa² (AUTHOR), Passeri, Thibault³ (AUTHOR), Duranteau, Lise⁴ (AUTHOR), Coste, Joël^5,6 (AUTHOR), Froelich, Sébastien³ (AUTHOR), Zureik, Mahmoud^1,7 (AUTHOR), Weill, Alain¹ (AUTHOR)

Source: European Journal of Neurology. Jan2025, Vol. 32 Issue 1, p1-6. 6p.

Subject Terms: *DOSE-effect relationship in pharmacology, *MENINGIOMA, *COHORT analysis, *RISK assessment, *WOMEN'S health, *CONTRACEPTIVE drugs, *PROGESTATIONAL hormones

Strategy for Designing In Vivo Dose–Response Comparison Studies.

Authors: Novick, Steven¹ (AUTHOR) steven.novick@takeda.com, Zhang, Tianhui¹ (AUTHOR)

Source: Pharmaceutical Statistics. Jan/Feb2025, Vol. 24 Issue 1, p1-16. 16p.

Subject Terms: *IN vivo studies, *DOSE-effect relationship in pharmacology, *SAMPLE size (Statistics), *STATISTICAL power analysis, *TREATMENT effectiveness, *DRUG discovery

Astrocytic spermidine insufficiency contributes to enhanced pain sensitivity associated with ApoE4.

Authors: Yu, Kaiming, Zhou, Xiongyao, Li, Baolong, Sun, Jialu, Yang, Tuo, Li, Weizhen, Wang, Ningning, Gu, Xiaosong, Cui, Shusen, Cao, Rangjuan

Source: Journal of Headache & Pain; 5/15/2025, Vol. 26 Issue 1, p1-22, 22p

Subject Terms: NEURALGIA, BIOLOGICAL models, IN vitro studies, NF-kappa B, RESEARCH funding, NEUROGLIA, PAIN threshold, CELLULAR signal transduction, GENE expression, MICE, DOSE-effect relationship in pharmacology, AMINES, APOLIPOPROTEINS, ANIMAL experimentation, GENE expression profiling, METABOLOMICS, COMPARATIVE studies, NITRIC-oxide synthases, DISEASE risk factors, CHEMICAL inhibitors

Dexamethasone dose-dependently attenuates docetaxel-induced peripheral neuropathy in breast cancer treatment.

Authors: Kanno, Ryota, Saito, Yoshitaka, Takekuma, Yoh, Takahashi, Masato, Oshino, Tomohiro, Sugawara, Mitsuru

Source: Supportive Care in Cancer; May2025, Vol. 33 Issue 5, p1-8, 8p

Subject Terms: DEXAMETHASONE, DOCETAXEL, DRUG side effects, DOSE-effect relationship in pharmacology, PERIPHERAL neuropathy, BREAST cancer

Tafolecimab, a Third Monoclonal Antibody for PCSK9 as the Novel Lipid-Lowering Drug Around the World: A Narrative Review.

Authors: Liu, Hui-Hui, Li, Sha, Li, Jian-Jun

Source: Drugs; May2025, Vol. 85 Issue 5, p627-642, 16p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, THERAPEUTIC use of protease inhibitors, HYPERCHOLESTEREMIA, ANTILIPEMIC agents, PATIENT safety, MONOCLONAL antibodies, PROTEASE inhibitors, DOSE-effect relationship in pharmacology, DRUG efficacy, PHARMACODYNAMICS

Damiana (Turnera diffusa) Reduces Adipocyte Cell Differentiation and Ameliorates Myocyte Glucose Uptake.

Authors: Chae, Hee-Sung, Ahmed, Nessma H., Dale, Olivia R., Avula, Bharathi, Khan, Ikhlas A., Khan, Shabana I.

Source: Journal of Dietary Supplements; 2025, Vol. 22 Issue 3, p401-416, 16p

Subject Terms: GLUCOSE, RESEARCH funding, FAT cells, LIPIDS, FLAVONOIDS, CELLULAR signal transduction, PHYTOCHEMICALS, DESCRIPTIVE statistics, HYPOGLYCEMIC agents, PLANT extracts, DOSE-effect relationship in pharmacology, MEDICINAL plants, METABOLISM, METABOLIC syndrome, MASS spectrometry, CELL differentiation, PEROXISOME proliferator-activated receptors, CELLS, DNA-binding proteins, NUCLEAR factor E2 related factor, GLYCOSIDASES, CELL receptors

Physiologically based Pharmacokinetic/Pharmacodynamic Modeling (PBPK/PD) of Famotidine in Pregnancy.

Authors: Liu, Xiaomei I., Green, Dionna J., van den Anker, John, Ahmadzia, Homa K., Calderon, Joaquin, Burckart, Gilbert J., Dallmann, André

Source: Journal of Clinical Pharmacology; May2025, Vol. 65 Issue 5, p564-574, 11p

Subject Terms: BIOLOGICAL models, HYDROGEN-ion concentration, PREDICTION models, RECEIVER operating characteristic curves, GASTRIC acid, RESEARCH funding, HEARTBURN, DESCRIPTIVE statistics, DOSE-effect relationship in pharmacology, ANTIHISTAMINES, GESTATIONAL age, FAMOTIDINE, COMPARATIVE studies, CONFIDENCE intervals, GASTROESOPHAGEAL reflux, PHARMACODYNAMICS, PREGNANCY

Effect of pretreatment with low-dose Esketamine on the Propofol requirements and the onset time of cisatracurium during the induction of general anesthesia: a prospective, randomized, double-blinded trial.

Authors: An, Rui, Lin, Chunnan, Lu, Zeguang, Lin, Wenqian, Tan, Hongying, Zhang, Tianhua, Li, Huiting, Cao, Longhui

Source: BMC Anesthesiology; 4/28/2025, Vol. 25 Issue 1, p1-8, 8p

Subject Terms: ATRACURIUM, KETAMINE, BLIND experiment, STATISTICAL sampling, INTRAVENOUS anesthetics, TREATMENT effectiveness, RANDOMIZED controlled trials, PROPOFOL, DOSE-effect relationship in pharmacology, LONGITUDINAL method, GENERAL anesthesia, NEUROMUSCULAR blocking agents, TIME, EVALUATION

Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China.

Authors: Wu, Qingyue, Yang, Jingyuan, Zhou, Xunqiong, Chen, Mingyan, Yang, Xing

Source: Frontiers in Aging Neuroscience; 2025, p1-11, 12p

Subject Terms: COGNITION disorder risk factors, ARM physiology, RISK assessment, CROSS-sectional method, CLUSTER analysis (Statistics), EXERCISE, COGNITIVE testing, RESEARCH funding, STATISTICAL sampling, MULTIPLE regression analysis, SMOKING, SEX distribution, DISEASE prevalence, LONGITUDINAL method, ODDS ratio, DOSE-effect relationship in pharmacology, COGNITION disorders, RURAL conditions, RURAL population, SYSTOLIC blood pressure, CONFIDENCE intervals, EARLY diagnosis, PSYCHOLOGICAL tests, BLOOD pressure measurement, HYPOTENSION, DISEASE complications, OLD age

Geographic Terms: CHINA

Incidence and predictors of postoperative delirium following remimazolam administration: a systematic review and meta-analysis of 29 randomized trials.

Authors: Li, Chao, Wei, Lai, Gong, Hong, Yuan, Xingxing

Source: BMC Anesthesiology; 4/23/2025, Vol. 25 Issue 1, p1-23, 23p

Subject Terms: BENZODIAZEPINES, RISK assessment, SURGERY, PATIENTS, CANCER patient medical care, TRANQUILIZING drugs, META-analysis, AGE distribution, DESCRIPTIVE statistics, SURGICAL complications, SYSTEMATIC reviews, MEDLINE, ORTHOPEDIC surgery, DOSE-effect relationship in pharmacology, DELIRIUM, MEDICAL databases, ONLINE information services, CONFIDENCE intervals

Prospective in-depth analysis of anaesthetic management of spontaneous ventilation VATS for lung cancer resection: a matched pairs comparison to intubated VATS.

Authors: Mihatsch, Lorenz L., Huber, Anastasia, Weiland, Sandra, Friederich, Patrick

Source: BMC Anesthesiology; 4/16/2025, Vol. 25 Issue 1, p1-14, 14p

Subject Terms: VIDEO-assisted thoracic surgery, THREE-dimensional imaging, PAIRED comparisons (Mathematics), RESPIRATION, THORACIC surgery, CHEST X rays, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, TRACHEA intubation, LONGITUDINAL method, DOSE-effect relationship in pharmacology, LUNG tumors, ARTIFICIAL respiration, DIGITAL image processing, ANESTHESIA, BRONCHI, EVALUATION